Can you iv meperidine

The temperature at which the horse responded to the stimulus stomping, lifting, pawing with or touching their nose to the right front leg was recorded as the threshold temperature for the time point. Baselines were also taken in triplicate the morning of drug administration with a 5-minute interval between each reading. Thermal readings were obtained 15, 30, 45, 60, 90, , , and minutes after administration of meperidine or saline.

Where T T represents the thermal threshold, T 0 the skin temperature and T C the thermal nociceptive cut-off temperature. For pharmacokinetic analysis, differences in parameters between dose groups were assessed and for pharmacodynamic data, differences between baseline and each time point and between dose groups were evaluated. Data were analyzed using a mixed effects analysis of variance, with the horse as the random effect and time and dose as the fixed effects.

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Effects of transdermal lidocaine or lidocaine with prilocaine or tetracaine on mechanical superficial sensation and nociceptive thermal thresholds in horses. Download references. Financial support for this project was provided by the Center for Equine Health with funds provided by the State of California pari-mutuel fund.

Additional funding was provided by the California Horse Racing board. The funding bodies had no role in the design of the study, data collection, analysis and interpretation of data or in writing the manuscript. Briana D. Hamamoto-Hardman, Daniel S. You can also search for this author in PubMed Google Scholar. BDHH- study execution, data analysis, manuscript preparation, reviewed and approved final manuscript; EPS-study design, reviewed and approved final manuscript; DSM-study execution, data analysis, manuscript preparation, reviewed and approved final manuscript; PHK-data analysis, manuscript preparation, reviewed and approved final manuscript; HKK-study design, study execution, data analysis, manuscript preparation, reviewed and approved final manuscript.

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Reprints and Permissions. Hamamoto-Hardman, B. Meperidine pharmacokinetics and effects on physiologic parameters and thermal threshold following intravenous administration of three doses to horses.

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A nurse or other trained health professional will give you this medicine in a hospital. This medicine is given through a needle placed in one of your veins, or as a shot under your skin or in a muscle. Meperidine may sometimes be given at home to patients who do not need to be in the hospital or clinic. If you are using this medicine at home, your doctor or nurse will teach you how to prepare and inject the medicine.

Be sure that you understand how to use the medicine. You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas.

This will help prevent skin problems from the injections. You might not use all of the medicine in each ampul or cartridge. Use each ampul or cartridge only one time. If the medicine in the vial or syringe has changed color, or if you see particles in it, do not use it. Throw away used needles in a hard, closed container that the needles cannot poke through.

Keep this container away from children and pets. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. It is very important that your doctor check your progress while you are receiving this medicine.

This is to make sure that the medicine is working properly, and to allow your doctor to check for any unwanted effects. Using these medicines together may cause unwanted effects, such as confusion, agitation, restlessness, stomach or intestinal symptoms, a sudden high temperature, an extremely high blood pressure, or convulsions. Symptoms of an overdose include extreme dizziness or weakness, slow heartbeat or breathing, seizures, trouble breathing, and cold, clammy skin.

Call your doctor right away if you notice these symptoms. This medicine will add to the effects of alcohol and other CNS depressants medicines that can make you drowsy or less alert. Some examples of CNS depressants are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicine, other prescription pain medicine or narcotics, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics.

Check with your doctor before taking any of the medicines listed above while you are using this medicine. This medicine may cause sleep-related breathing problems eg, sleep apnea, sleep-related hypoxemia. Your doctor may decrease your dose if you have sleep apnea stop breathing for short periods during sleep while using this medicine. This medicine may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose.

Call your doctor for instructions. Drinking alcohol, taking prescription or nonprescription medications that contain alcohol, or using street drugs during your treatment with meperidine increases the risk that you will experience serious, life-threatening side effects.

Do not drink alcohol, take prescription or nonprescription medications that contain alcohol, or use street drugs during your treatment. Do not allow anyone else to use your medication. Meperidine injection may harm or cause death to other people who use your medication, especially children. Tell your doctor if you are pregnant or plan to become pregnant.

If you using meperidine injection regularly during your pregnancy, your baby may experience life-threatening withdrawal symptoms after birth.

Tell your baby's doctor right away if your baby experiences any of the following symptoms: irritability, hyperactivity, abnormal sleep, high-pitched cry, uncontrollable shaking of a part of the body, vomiting, diarrhea, or failure to gain weight.

Read the information carefully and ask your doctor or pharmacist if you have any questions. Meperidine injection is used to relieve moderate to severe pain.

It may also be used before and during surgery or other medical procedures. Meperidine injection is in a class of medications called opiate narcotic analgesics. It works by changing the way the body senses pain. Meperidine injection comes as a solution liquid to inject subcutaneously just under the skin , intramuscularly into a muscle , or intravenously into a vein.

It is usually injected subcutaneously or intramuscularly once every 3 to 4 hours as needed. Your doctor may adjust your dose of meperidine injection during your treatment, depending on how well your pain is controlled and on the side effects that you experience.

Talk to your doctor about how you are feeling during your treatment with meperidine injection. If you have used meperidine injection for longer than a few days, do not stop using it suddenly. If you suddenly stop using meperidine injection, you may experience withdrawal symptoms including restlessness; teary eyes; runny nose; yawning; sweating; chills; muscle, back or joint pain; widening of the pupils; irritability; anxiety; weakness; stomach cramps; difficulty falling asleep or staying asleep; nausea; loss of appetite; vomiting; diarrhea; fast breathing; or fast heartbeat.

Your doctor will probably decrease your dose gradually. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. Meperidine injection may cause other side effects. Call your doctor if you have any unusual problems while using this medication. While using meperidine injection, you should talk to your doctor about having a rescue medication called naloxone readily available e.

Naloxone is used to reverse the life-threatening effects of an overdose. It works by blocking the effects of opiates to relieve dangerous symptoms caused by high levels of opiates in the blood. Your doctor may also prescribe you naloxone if you are living in a household where there are small children or someone who has abused street or prescription drugs.

You should make sure that you and your family members, caregivers, or the people who spend time with you know how to recognize an overdose, how to use naloxone, and what to do until emergency medical help arrives.

Your doctor or pharmacist will show you and your family members how to use the medication. Ask your pharmacist for the instructions or visit the manufacturer's website to get the instructions. If symptoms of an overdose occur, a friend or family member should give the first dose of naloxone, call immediately, and stay with you and watch you closely until emergency medical help arrives.